Glucan is the most physiologically active with β-glucan. In the 1940s, Dr. Pillemer first discovered and reported that there is a substance in the yeast cell wall that has the effect of improving immunity. Later, after further research by Dr. Diluzio of Tulum University, the immune-enhancing substance in the yeast cell wall was a polysaccharide, β-glucan, which was isolated from baker's yeast.
The β-glucan active structure is a polysaccharide composed of glucose units, most of which are bound by β-1,3, which is a glucose chain linkage. It can activate macrophages and neutrophils, thus increasing the levels of leukocytes, cytokinins and specific antibodies, and fully stimulating the body's immune system. Then, the body is more prepared to fight the diseases caused by microorganisms. Β-glucan can quickly restore the ability of injured lymphocytes to produce cytokines (IL-1), and effectively regulate the body's immune function. A large number of experiments have shown that β-glucan can promote the production of IgM antibodies in vivo to improve humoral immunity. This glucan-activated cell stimulates the host's non-specific defense mechanism, so it has attracted much attention in tumors, infectious diseases and therapeutic wounds. Extracted by special procedures and without endotoxin β-1,3 glucan has been identified as a safe substance in the US FDA and can be added to general foods. Many reports show that mice are orally administered yeast β-1,3 glucan. Increase the antibacterial phagocytosis of strong peritoneal cells. 
Yeast glucan is a polysaccharide with enhanced immunity activity in the yeast cell wall, β-glucan. Β-glucan is widely present in various fungi and plants, such as mushrooms, ganoderma lucidum, and oats, and is a main efficacious substance for their health effects. The yeast glucan immunopotentiating activity is stronger, and has the effects of improving blood lipids and anti-radiation, and improving intestinal function.